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# CITATION.cff file created with {cffr} R package
# See also: https://docs.ropensci.org/cffr/
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cff-version: 1.2.0
message: 'To cite package "flippant" in publications use:'
type: software
license: GPL-3.0-or-later
title: 'flippant: Dithionite Scramblase Assay Analysis'
version: 1.5.7
doi: 10.1186/s12859-017-1542-y
identifiers:
- type: doi
  value: 10.32614/CRAN.package.flippant
abstract: The lipid scrambling activity of protein extracts and purified scramblases
  is often determined using a fluorescence-based assay involving many manual steps.
  flippant offers an integrated solution for the analysis and publication-grade graphical
  presentation of dithionite scramblase assays, as well as a platform for review,
  dissemination and extension of the strategies it employs. The package's name derives
  from a play on the fact that lipid scrambling is also sometimes referred to as 'flipping'.
  The package is originally published as Cotton, R.J., Ploier, B., Goren, M.A., Menon,
  A.K., and Graumann, J. (2017). "flippant–An R package for the automated analysis
  of fluorescence-based scramblase assays." BMC Bioinformatics 18, 146. <DOI:10.1186/s12859-017-1542-y>.
authors:
- family-names: Graumann
  given-names: Johannes
  email: johannes.graumann@uni-marburg.de
- family-names: Cotton
  given-names: Richard
  email: richierocks@gmail.com
preferred-citation:
  type: article
  title: flippant–An R package for the automated analysis of fluorescence-based scramblase
    assays
  authors:
  - family-names: Cotton
    given-names: Richard J.
  - family-names: Ploier
    given-names: Birgit
  - family-names: Goren
    given-names: Michael A.
  - family-names: Menon
    given-names: Anant K.
  - family-names: Graumann
    given-names: Johannes
    email: johannes.graumann@uni-marburg.de
  volume: '18'
  issn: 1471-2105
  url: http://dx.doi.org/10.1186/s12859-017-1542-y
  doi: 10.1186/s12859-017-1542-y
  abstract: The lipid scrambling activity of protein extracts and purified scramblases
    is typically measured using a fluorescence-based assay. While the assay has yielded
    insight into the scramblase activity in crude membrane preparations, functional
    validation of candidate scramblases, stoichiometry of scramblase complexes as
    well as ATP-dependence of flippases, data analysis in its context has remained
    a task involving many manual steps.
  journal: BMC Bioinformatics
  date-accessed: '2017-03-03'
  date-published: '2017-03-03'
  keywords:
  - R
  - Scramblase
  - Dithionite scramblase assay
  year: '2017'
  start: '146'
  month: '3'
repository: https://r-cheologist.r-universe.dev
commit: 26848bd26802183e7b623c761749cf3d96f13eba
date-released: '2025-09-09'
contact:
- family-names: Graumann
  given-names: Johannes
  email: johannes.graumann@uni-marburg.de